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Contraindicated (1)pentobarbital will lessen the level or result of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the level or result of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.pentobarbital will reduce the extent or impact of iri